Bioorthogonal oxime ligation mediated in vivo cancer targeting† †Electronic supplementary information (ESI) available: Synthesis and characterization of compounds and nanoparticles, in vitro and in vivo tumor cell labelling with liposomes, PET/CT imaging and biodistribution. See DOI: 10.1039/c5sc00063g Click here for additional data file.

Bioorthogonal oxime ligation mediated in vivo cancer targeting

Department of Materials Science and Urbana–Champaign, 1304 West Green S [email protected]; Fax: +1-217-333-2736 Department of Pharmaceutical Science, Guangzhou, Guangdong, 510006, China Department of Bioengineering, University o IL 61801, USA † Electronic supplementary informatio characterization of compounds and nan cell labelling with liposomes, PET/CT im 10.1039/c5sc00063g ‡ Contributed ...

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo † †Electronic supplementary information (ESI) available: Experimental materials and methods, characterization details of all compounds, X-ray crystal structures. CCDC 1499561 and 1499562. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc03862j Click here for additional data file. Click here for additional data file.

Emissive nanoparticles from pyridinium-substituted tetraphenylethylene salts: imaging and selective cytotoxicity towards cancer cells in vitro and in vivo by varying counter anions† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc02395a Click here for additional data file.

Chemotherapeutics specifically targeting cancer cells without damaging healthy cells is the long-awaited goal of cancer treatment. In this paper, a series of nanoparticles (NanoTPES 1–4) assembled from pyridinium-substituted tetraphenylethylene salts were synthesized and investigated both in vitro and in vivo for this purpose. By changing the counter anions, NanoTPES 1–4 exhibit tunable emissio...

Micro-flow photosynthesis of new dienophiles for inverse-electron-demand Diels–Alder reactions. Potential applications for pretargeted in vivo PET imaging† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc02933g Click here for additional data file.

Pretargeted PET imaging has emerged as an effective two-step in vivo approach that combines the superior affinity and selectivity of antibodies with the rapid pharmacokinetics and favorable dosimetry of smaller molecules radiolabeled with short-lived radionuclides. This approach can be based on the bioorthogonal inverse-electron-demand Diels–Alder (IEDDA) reaction between tetrazines and trans-c...

Supramolecularly engineered phospholipids constructed by nucleobase molecular recognition: upgraded generation of phospholipids for drug delivery† †Electronic supplementary information (ESI) available: Synthesis detail and characterization of supramolecular nucleoside phospholipids; fabrication of supramolecular liposomes and conventional liposomes, including fabrication of DOX-loaded supramolecular liposomes and conventional liposomes; details of in vitro experiments, including in vitro cytotoxicity studies, intracellular drug release, examination of cell viability of MCF-7 cells, apoptosis analyses and western blotting analysis; details of in vivo experiments, including pharmacokinetic studies, in vivo biodistribution and tumor targeting capability in tumor-bearing mice and in vivo antitumor efficacy. See DOI: 10.1039/c5sc01188d